Cadiz

In the later Middle Ages, Cadiz was the main Atlantic port belonging to the Crown of Castile, having passed from Muslim to Christian control in 1262. (Castile also had a port on the Mediterranean coast at Cartageña, but the Emirate of Granada separated the two sections of coastline.) As Europeans' maritime focus shifted from the Mediterranean to the Atlantic, Cadiz grew into Spain's most important port: Columbus began his second and fourth voyages to Hispaniola from Cadiz, and it later became the home port for the Spanish fleets traveling between the Old and New Worlds. Campbell #279.